Opportunistic bacterial vaginitis in women with spontaneous pregnancy loss
DOI:
https://doi.org/10.56286/n4e8fa82Keywords:
Opportunistic, Vaginitis, Spontaneous Pregnancy Loss, Carbapenemase, beta-lactam resistanceAbstract
Background
Opportunistic bacterial vaginitis is increasingly recognized as a factor in adverse pregnancy outcomes, such as spontaneous pregnancy loss. The alteration of the vaginal microbiota can facilitate the proliferation of pathogenic organisms, including E. coli, Staphylococcus spp., and Klebsiella spp., which are linked to inflammation, infection, and adverse reproductive outcomes.
Aim
This study intends to examine the prevalence and patterns of antibiotic susceptibility of bacterial and fungal pathogens in women who are having spontaneous abortions in order to guide focused interventions to enhance maternal-fetal health outcomes.
Materials and Methods
100 women with a history of spontaneous abortions, 17 to 50 years old, were involved. HVS was collected and cultivated. After biochemical tests identified the isolates, the Vitek2 method was used.
Results
34% of women with SA had positive microbiological cultures. primarily Candida spp. (26.5%). E. coli (14.7%), Staph. aureus (11.8%), and Klebsiella spp. (8.8%) were the most prevalent pathogens. Women with at least four abortions had higher infection rates, particularly for Candida spp. and E. coli. High beta-lactam resistance was demonstrated by Klebsiella spp. and E. coli, with some strains exhibiting carbapenem resistance, suggesting the potential production of carbapenemase. Gram-positive isolates that demonstrated multidrug resistance through mecA and MLSB mechanisms included Staph. haemolyticus and Staph. aureus. Linezolid and tigecycline continued to work against the majority of resistant strains.
Conclusion
The findings highlight the critical need for updated, region-specific antibiotic guidelines and routine microbial screening in the early stages of pregnancy.
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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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