Estimation of GOT, GPT and ALP in type 1 Diabetes Mellitus Patients

Abstract

Background: In comparison to the broader public, Patients with diabetes are more likely to have elevated liver enzymes.Alcoholic  hepatosteatosis that is not caused by alcohol is frequently seen in this syndrome.

Materials and Methods: In a cross-sectional study in the Kirkuk governorate of Iraq, 25 patients who are type 1 diabetes and 26 healthy individuals served as the control group. Both groups completed questionnaires that asked about their age, weight, body mass index (BMI), and checked their  liver enzymes GOT, GPT, and ALT.

Results: The study discovered that 19 patients, or 76%, fell within the normal range (BMI 25), whereas 5 patients, or 20%, were overweight, and 1 patient, or 4%, was obese. The study also found no association between GPT and gender, but a strong substantial correlation between GOT and gender  While there is no association between diabetes patients' gender and GPT. Additionally, this study demonstrated a high significant (P? 0.001) rise in ALP value (72.05±7.74) IU/L versus (62.4±7.38) IU/L for the control group, but a significant (P ? 0.05)  rise in GOT (24.25±4.13) IU/L so GPT (31.8±6.1) IU/L values for patients compared with the control group(21.3±4.95 and 26.7±7.28 IU/L respectively).

Conclusion: The type 1 diabetic patients could be at danger for CVD due to possible obesity. GOT, GPT, and ALP values were elevated in the sick set than in healthy group. Male patients had higher GOT and GPT enzyme levels than female patients.