Selected Laboratory Markers in Early-Phase Acute Myocardial Infarction and Their Association with Cardiac Troponin I

Abdulrahman Akram Hussien; Mohammed Fadhil Haddad; Barbaros  Nalbantoğlu

doi:10.56286/q6gyqd93

Authors

Abdulrahman Akram Hussien Department of Medical Laboratory Techniques, College of Health and Medical Techniques, Northern Technical University, 36001 Kirkuk, Iraq https://orcid.org/0009-0004-7534-7436
Mohammed Fadil Haddad Department of Medical Laboratory Techniques, Mosul Medical Technical Institute, Northern Technical University, 41002 Mosul, Iraq https://orcid.org/0000-0002-9319-6502
Barbaros Nalbantoğlu Department of Biochemistry, Faculty of Arts and Science, Yildiz Technical University, 34220 Istanbul, Türkiye https://orcid.org/0000-0002-2718-1855

DOI:

https://doi.org/10.56286/q6gyqd93

Keywords:

acute myocardial infarction, C-reactive protein, HDL cholesterol, AST, metabolic markers, troponin I

Abstract

Background: Acute myocardial infarction (AMI) is a major cause of morbidity and mortality in the world. Early diagnosis can minimize complications and improve patient outcomes. Objectives: To assess biochemical, inflammatory, and metabolic parameters in early-phase AMI patients and evaluate their correlation with cardiac troponin I (cTnI). Methods: A case control study was conducted in Al-Ramadi General Hospital, Anbar, Iraq during December 2025 to April 2026. 60 AMI patients and 40 healthy controls were recruited. The serum levels of cardiac troponin I (cTnI), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), C-reactive protein (CRP), random blood sugar (RBS), potassium (K), calcium (Ca), triglycerides, total cholesterol, and high-density lipoprotein (HDL) were measured. Results: cTnI was significantly elevated in patients with AMI compared with controls (median 0.33 vs. 0.01 ng/mL, p < 0.001). AST, CRP, and RBS levels were also significantly higher, whereas serum calcium and HDL cholesterol were significantly lower in AMI patients (all p < 0.01). Significant negative correlations were observed between triglycerides and HDL, and between total cholesterol and HDL, while cTnI showed a positive correlation with AST. Conclusion: Early-phase AMI is associated with significant biochemical, inflammatory, and metabolic alterations alongside elevated cTnI. Notable features of AMI include low calcium, high CRP, high glucose and low HDL cholesterol, all of which can be helpful adjunct indicators in the clinical assessment.

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Author Biographies

Abdulrahman Akram Hussien, Department of Medical Laboratory Techniques, College of Health and Medical Techniques, Northern Technical University, 36001 Kirkuk, Iraq

M.Sc. student, Medical Laboratory Techniques Department, College of Health and Medical Technology, Northern Technical University, Kirkuk, Iraq
Mohammed Fadil Haddad, Department of Medical Laboratory Techniques, Mosul Medical Technical Institute, Northern Technical University, 41002 Mosul, Iraq

Medical Laboratory Techniques Department, Mosul Medical Technical Institute, Northern Technical University, Mosul, Iraq
Barbaros Nalbantoğlu, Department of Biochemistry, Faculty of Arts and Science, Yildiz Technical University, 34220 Istanbul, Türkiye

Faculty of Arts and Science, Department Of Chemistry, Yildiz Technical University, Istanbul, Türkiye

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