Indirect Spectrophotometric Determination of Metformin Via Decolorization Eriochrome Black-T
DOI:
https://doi.org/10.56286/ntujps.v2i4.737Keywords:
Metformin, Spectrophotometric, Decolorization, Eriochrome Black-TAbstract
The research included the description of a simple indirect spectrophotometric method for the determination of Metformin, which depended on the oxidation of Metformin with an amount of N- bromosuccinimide in the presence of acetic acid and the excess amount of it oxidized the dye Eriochrome black-T, and the absorption was measured at 520 nm, and the molar absorption coefficient was 4 × 104 L / mol. cm, indicating the sensitivity of the method. And compliance with Beer's law for concentrations ranged from (2-16) micrograms. ML-1, the method was characterized by good accuracy and compatibility, with a recoverability of 100.155%. While the relative standard deviation was less than 1.0.The method was applied to
pharmaceutical preparations of Metformin hydrochloride.
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