Association of H. pylori IgG and CagA-IgG with Some Immunological and Biochemical Parameters in Diabetic Patients
DOI:
https://doi.org/10.56286/ntujps.v3i1.511Keywords:
Helicobacter pylori, Diabetes Mellitus II, Interleukin-1?, Interlukin-10, Cag AAbstract
Helicobacter pylori is a gram-negative bacteria that can cause gastric and extra-gastric diseases. The study aimed to find the relationship between infection with H. pylori and the progression of diabetes type II(DMII) with other immunological markers. Method This study was conducted in Kirkuk City from Nov. 2022 to Apr. 2023 and included 106 individuals, 26 as a control group and 80 patients (34 males and 46 females) suffering from (DMII) with H. pylori infection. Five ml of venous blood were taken for HbA1c, fast serum glucose, serum H. pylori IgG, H. pylori CagA IgG, Interlukin-1?, and IL-10 tests. Results The correlation factor (p< 0.01) had shown that there was a weak positive correlation between HbA1c and H. pylori IgG titer, as well as a moderate positive correlation between the levels of H. pylori CagA IgG and IL-1?. There was a moderate negative correlation between the levels of HbA1c and IL-10, also between IL-1? and IL-10 levels.. Conclusion There was a relationship between the severity of infection with H. pylori and high HbA1c levels. In addition, CagA has a significant impact on increasing the severity of inflammation by increasing IL-1? secretion.
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